DFB cup 1st round
SV Wehen Wiesbaden - BVB 0:3
7. August 2021
1st match day
BVB - Eintracht Frankfurt 5:2
14. August 2021
DFL-Supercup
BVB - Bayern München 1:3
17. August 2021
2nd match day
SC Freiburg - BVB 0:3
21. August 2021
3rd match day
BVB - Hoffenheim 3:2
27. August 2021
4th match day
Bayer Leverkusen - BVB 3:4
11. September 2021
1st match day UCL
Besiktas - BVB 1:2
15. September 2021
5th match day
BVB - Union Berlin 4:2
19. September 2021
6th match day
Bor. M'gladbach - BVB 1:0
25. September 2021
2nd match day UCL
BVB - Sporting CP 1:0
28. September 2021
7th match day
BVB - FC Augsburg 2:1
2. October 2021
8th match day
BVB - Mainz 05 3:1
16. October 2021
3rd match day UCL
Ajax - BVB 4:0
19. October 2021
9th match day
Arminia Bielefeld - BVB 1:3
23. October 2021
DFB cup 2nd round
BVB - FC Ingolstadt 2:0
26. October 2021
10th match day
BVB - 1. FC Köln 2:0
30. October 2021
4th match day UCL
BVB - Ajax 1:3
3. November 2021
11th match day
Rasenballsport Leipzig - BVB 2:1
6. November 2021
12th match day
BVB - VfB Stuttgart 2:1
20. November 2021
5th match day UCL
Sporting CP - BVB 3:1
24. November 2021
13th match day
VfL Wolfsburg - BVB 1:3
27. November 2021
14th match day
4. December 2021
6th match day UCL
BVB - Besiktas 5:0
7. December 2021
15th match day
VfL Bochum - BVB 1:1
11. December 2021
16th match day
BVB - Greuther Fürth 3:0
15. December 2021
17th match day
Hertha BSC - BVB 3:2
18. December 2021
18th match day
Eintracht Frankfurt - BVB 2:3
8. January 2022
19th match day
BVB - SC Freiburg 5:1
14. January 2022
DFB cup round of 16
FC St. Pauli - BVB 2:1
18. January 2022
20th match day
TSG Hoffenheim - BVB 2:3
22. January 2022
21st match day
BVB - Bayer Leverkusen 2:5
6. February 2022
22nd match day
Union Berlin - BVB 0:3
13. February 2022
Round of 16, first leg UCL
BVB - Rangers 2:4
17. February 2022
23rd match day
BVB - Bor. M'gladbach 6:0
20. February 2022
Round of 16, second leg UCL
Rangers - BVB 2:2
24. February 2022
24th match day
FC Augsburg - BVB 1:1
27. February 2022
25th match day
BVB - Arminia Bielefeld 1:0
13. March 2022
26th match day
Mainz 05 - BVB 0:1
16. March 2022
27th match day
1. FC Köln - BVB 1:1
20. March 2022
28th match day
Rasenballsport Leipzig - BVB 1:4
2. April 2022
29th match day
VfB Stuttgart - BVB 0:2
8. April 2022
30th match day
BVB - VfL Wolfsburg 6:1
16. April 2022
31st match day
Bayern München - BVB 3:1
23. April 2022
32nd match day
BVB - VfL Bochum 3:4
30. April 2022
33rd match day
Greuther Fürth - BVB 1:3
7. May 2022
34th match day
BVB - Hertha BSC 1:3
14. May 2022
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